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John Macleod 🔼
John James Rickard Macleod –
(6 September 1876 – 16 March 1935)
He was a British biochemist & physiologist.
He devoted his career to Carbohydrate Metabolism.
He is noted for his role in the discovery and isolation of Insulin.
For which he and Frederick Banting received the 1923 Nobel Prize in Physiology or Medicine.
🔺 John Macleod’s Book –
A NOTICE of an earlier edition of this work appeared in NATURE of December 18, 1919 (p. 389). That a new edition should be required in a year’s time shows that the book has been found to meet the purpose for which it was written. The opportunity has been taken to recast the section on the nervous system, which has been excellently done by Dr. Redfield adding to it an account of the fundamental principles of the physiology of muscle and nerve. These changes will add to the value of the book to those for whom it is primarily intended, particularly to the medical man who wishes to apply advances in physiology to his clinical practice. Recent work on such questions as the effects of deficient oxygen supply, on “vitamins,” on the capillary circulation, and on wound shock has been duly incorporated. A good account of the problem of the carriage of oxygen and carbon dioxide in the blood, still a disputed one, will also be found. Although the price of the book seems rather high, it may reasonably be held that good value is obtained. It might be worth consideration, however, whether the omission of some of the coloured plates would not enable a wider circulation to be ensured by a lower price. The further such knowledge as that contained in the book is spread, the better will it be for the advance of medical science and practice.
❤️ INSULIN :-
Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the INS gene.
It is considered to be the main anabolic hormone of the body.
It regulates the metabolism of carbohydrates, fats & protein by promoting the absorption of glucose from the blood into liver, fat & skeletal muscle cells.
🔺 Insulin : First experiment on dog
In January 1922, the team performed the first successful clinical trial, on 13-year-old Leonard Thompson, and it was soon followed by others.
Diabetes: Its Pathological Physiology,1913
Macleod’s presentation at a meeting of the Association of American Physicians in Washington, D.C., on 3 May 1922 received a standing ovation.
At that time, demonstrations of the method’s efficiency drew huge public interest, because the effect on patients, especially children, who until then were bound to die, seemed almost miraculous.
The pharmaceutical company Eli Lilly & Co. took over mass production, but without an exclusive license, as the patent was transferred to the British Medical Research Council to prevent exploitation.
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