writer : jotsna jari
❤️ Albert Claude joined the Rockefeller cancer laboratory of James B. Murphy in 1929, with the goal of using biochemical methods to isolate the Rous sarcoma virus.
At the time, scientists still debated whether this tumor-causing agent, discovered in 1911 at Rockefeller by Peyton Rous, was a virus.
In order to isolate the agent, Claude used a mortar and pestle to gently break open infected cells, then he centrifuged the contents to separate sub-cellular components by their density into “fractions” that could then be analyzed biochemically.
He remained at Rockefeller until 1949 when he became director of the Jules Bordet Institute at the University of Brussels.
❤️Albert Claud’s personal writing :-
The population was sparse, at least at the time I was a boy. Our agglomeration was made of scattered small farms, regrouped into hamlets which, with the village, amounted to about 800 inhabitants in all. Rarely, because the people were few, a funeral procession was climbing slowly from the valley, back of our house, and to the old church next to the Charlemagne farm, with the cemetery between them.
The unique school of the Longlier region was built at the outskirt, a kilometer from my home, and about equal distance from the surrounding hamlets, so that the children could leave their home, and reach the school at about the same time. Actually, this school was just a single room with high windows, and a central stove, fed with coal and wood, by the teacher himself. As I remember, there was a set of 5 benches at either side of the stove, with a common sitting board which could accommodate 5 children, in all 50 seats, for an average population, from year to year, of 40 pupils, at the most. The sexes and grades were mixed, and the ages, from 6 to 11 years old. All the courses were taught at the same time, in the same room, by the same and unique teacher. Under this highly pluralistic system, the school was running smoothly, and the results, as remembered over the years, turned out to be, in every respect, excellent.
As usual for the time, the roads were not lighted at night, and no water distribution was available, nor in prospect. Due to the elevation of the site, we had to rely on rainwater, collected from the roofs, and on the clear water, filtering and running from the bare rocks, to the river and the streams below.
In the Ardennes, the washed soil is poor, and the configuration rugged. When the spring and summer came, the heat of the sun brought life and beauty to the land. The farmers, however, rose early and worked late, each on their farm, relatively far apart, without the occasion, or the need, to communicate between themselves. Even more than in the cold of the winter, there was a strange stillness, in the heat of the afternoon.
After supper, and when the daily work was over, we did not light the kerosene lamp, nor the makeshift carbide lamp we used, when the war came upon us, but sat outdoors, in the silence and the darkness of the night. As many have done before us, since the early rise of mankind, I reclined on the sloping back of a chair, and gazed intensely, and for hours, at the quivering milky way, and watched the coming of falling stars.
When I became old enough, I took my turn in getting up early, and ringing the church bells (there were two of them) calling for the daily mass, at six o’clock in the morning. The ropes of the bells were hanging freely down the hollow shaft of the church tower, so that we could seize them and pull them from the ground, with the bells seen overhead. When the bells were in full swing, we used to grasp the rope firmly and let ourselves be lifted, just when the hammer hit the roaring bronze. This little familiarity had created an affectionate and reciprocal understanding between us and the Bells. One night, during a heavy storm, we were awakened by a crash. The Pepin le Bref tower, as it was called, which had stood there for many centuries had collapsed, bringing down, with it, the church bells. A few years later, in 1914, the madness of war reached our peaceful shores; the Charlemagne Villa, and part of the village, next to our home, was burnt. I was 15 years old, and starting to become an adult. For us, and for the dying Europe, and the thousands years of its past, it was a new World, and the end of an Era.
My grandfather was born in 1830, just the year the Flemish and French speaking Catholics decided to secede from the Lutheran Dutch people of the low lands, governed by the House of Orange. His place of birth was not Longlier. For a number of generations tracing back to the 17th century, his ancestors had been active in maintaining a Relay, or Stagecoach stop, providing horses, food and lodging for travellers, and wagons for the conveyance of goods. The site of this undertaking was a small plateau, about the locality of Offaing, rising from the opposite side of the Longlier valley, away and higher up from the Charlemagne Villa. From this rather ancient time, I have a witness helping me to imagine and recreate the past. It is a chest of heavy oak with a secret lock, and a slit with a receptacle underneath, in which the hostess, my great-grandmother, would drop the coins she received from the customers, in payment for their expenditure at the inn. This chest, for the past twenty years, has been in my bedroom, next to my bed, supporting a lamp and a clock.
My great-grandfather, Godfroid, born on the heights of Offaing in 1800, or about, had five or six sons, including my grandfather, and a similar number of daughters, most of them promised to live well over ninety. In this healthy, no doubt dynamic, but crowded environment, my grandfather may have felt the pressure of competition, but most likely happened to the most adventurous and most farsighted: he decided to move and settle on his own.
Following the Belgian revolution of 1830 the new nation decided to give itself a King, the choice being Léopold, Prince of Saxe-Cobourg and recent widower of the heir of the throne of England, with the crowning in 1831. Léopold the First was a man of high character and wisdom. It is to his knowledge of the industry of England and to his own initiative that Belgium owed to have had the first railroad lines on the Continent, the first one connecting Bruxelles with Antwerp and its harbor. The next undertaking was much more ambitious. This second line was to be transcontinental, starting from Brussels, through Namur, Luxembourg, Vienna, and further on.
The Longlier valley gap, however, which happened to stand exactly across the projected direction of the new railroad line, would have to be bridged. In addition to this technical difficulty, it was found that the Devonian synclinal, which is the geologic substructure of the region was disturbed by a tectonic anomaly in the form of a narrow band, less than one kilometer in width, which had become deflected in front of the Longlier valley, passing just under the terminal point where the construction of the railroad had stopped. The problems were such that the construction of the line was postponed, for an undetermined length of time. My grandfather saw the opportunity and moved to Longlier. Apparently, he was not without means. Within a relatively short time he built a hotel, next to the freight depot of the railroad terminus. From the commissioned Agency handling the freight traffic for the line, the “Messageries Van Gent”, he obtained some agreement whereby he would be responsible for the freight that landed at the Terminal, for its distribution outside the railroad areas. Very soon, he had horses and wagons distributing goods and wares in various directions, as far as the north of France, especially Sedan and Bazeilles, where we had some relatives. His business prospered rapidly, and he became relatively wealthy.
For me, this story of railroads and of a diligent grandfather, which I have recalled, has been more meaningful than the effect of a tectonic anomaly on a Devonian synclinal. Without the decision of my grandfather to move to Longlier, my mother would have been someone else, and there would have been no tales of ringing bells in a medieval church tower, and no ailing uncle to take care of. It was a question of being, or not being. Once the first step taken, what remains to deal with are the important but universal problems of the individual, versus his environment. My mother, Glaudice Watriquant, was 45 years old when I was born, and my father 43. I was the youngest of four, two brothers and one sister, with a gap of 9 years with the oldest. As it happened, most of my early years were spent in the company of old, or very old people, each having their problems and ailments, but never complaining. This created a pervading feeling of tolerance, kindness, and stoic strength which made me happy and feel secure.
( continuous… )
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